Micro and nano liposome vesicles containing curcumin for a drug delivery system
http://repository.vnu.edu.vn/handle/VNU_123/26692
Micro
and nano liposome vesicles were prepared using a lipidfilm hydration method and
a sonication method. Phospholipid, cholesterol and curcumin were used to form
micro and nano liposomes containing curcumin.
The
size, structure and properties of the liposomes were characterized by using
optical microscopy, transmission electron microscopy, and UV–vis and Raman
spectroscopy.
It
was found that the size of the liposomes was dependent on their composition and
the preparation method. The hydration method created micro multilamellars,
whereas nano unilamellars were formed using the sonication method.
By
adding cholesterol, the vesicles of the liposome could be stabilized and stored
at 4°C for up to 9 months. The liposome vesicles containing curcumin with good
biocompatibility and biodegradability could be used for drug delivery
applications.
| Title: | Micro and nano liposome vesicles containing curcumin for a drug delivery system |
| Authors: | Nguyen, Tuan Anh Tang, Quan Duoc Doan, Duc Chanh Tin Dang, Mau Chien |
| Keywords: | microliposome drug delivery curcumin nanoliposome |
| Issue Date: | 2016 |
| Publisher: | H. : ĐHQGHN |
| Citation: | ISIKNOWLEDGE |
| Abstract: | Micro and nano liposome vesicles were prepared using a lipidfilm hydration method and a sonication method. Phospholipid, cholesterol and curcumin were used to form micro and nano liposomes containing curcumin. The size, structure and properties of the liposomes were characterized by using optical microscopy, transmission electron microscopy, and UV–vis and Raman spectroscopy. It was found that the size of the liposomes was dependent on their composition and the preparation method. The hydration method created micro multilamellars, whereas nano unilamellars were formed using the sonication method. By adding cholesterol, the vesicles of the liposome could be stabilized and stored at 4°C for up to 9 months. The liposome vesicles containing curcumin with good biocompatibility and biodegradability could be used for drug delivery applications. |
| Description: | ADVANCES IN NATURAL SCIENCES-NANOSCIENCE AND NANOTECHNOLOGY Volume: 7 Issue: 3 ; 7 p. ; TNS06372 |
| URI: | http://repository.vnu.edu.vn/handle/VNU_123/26692 |
| Appears in Collections: | Bài báo của ĐHQGHN trong Web of Science |
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